{"id":"a48e8b94-efb6-44b5-bd5f-33796f8aff74","authors":[{"author":{"id":"1fdba2b5-5b16-47cf-8246-92c47dbfec7b","openalex_id":"pmc:author:turkistani_o","orcid":null,"display_name":"Turkistani O","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"2a7382a5-9b1f-43be-9a43-dbef7898cad2","openalex_id":"pmc:author:makhtoum_j","orcid":null,"display_name":"Makhtoum J","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"2af71ae1-48f3-4855-a882-3a2b16e36c84","openalex_id":"pmc:author:alzubaidi_k","orcid":null,"display_name":"Alzubaidi K","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"37842af5-2550-46a8-af1f-18f62911f96d","openalex_id":"pmc:author:alhammadi_m","orcid":null,"display_name":"Alhammadi M","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"571f5b1c-7708-4a43-8449-12e129c61f78","openalex_id":"pmc:author:aldraibi_s","orcid":null,"display_name":"Aldraibi S","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"first"},{"author":{"id":"6349b21e-0710-4ba0-b803-c6582b0b637a","openalex_id":"pmc:author:kassim_ab","orcid":null,"display_name":"Kassim AB","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"7864000e-892e-4032-8e39-0c4a2fadef42","openalex_id":"pmc:author:alghamdi_f","orcid":null,"display_name":"Alghamdi F","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"last"},{"author":{"id":"d6061eab-dc98-40e9-bb40-e529adee39d2","openalex_id":"pmc:author:alharbi_m","orcid":null,"display_name":"Alharbi M","works_count":8,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"e2a38802-e9cc-4d29-959f-7dae19fc87c8","openalex_id":"pmc:author:almutairi_d","orcid":null,"display_name":"Almutairi D","works_count":2,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"}],"concepts":[],"publisher_name":null,"publisher_website_url":null,"publisher_info":null,"bib_extra":[],"journal_info":null,"raw_data":{"abstract_tr":"ÖZET Arka Plan Fotodinamik tedavi ve kriyoterapi aktinik keratoz için tedavi seçenekleridir; ancak etkinlikleri ve güvenliği hâlâ tartışmalıdır. Amaç: Aktinik keratozda fotodinamik tedavi ve kriyoterapinin etkinliği ve güvenliğini inceleyen yüksek kaliteli sistematik bir inceleme ve meta-analiz yapmak. Yöntemler Sistematik İncelemeler ve Meta-Analizler için Tercih Edilen Raporlama Öğeleri rehberleri uygulanarak sistematik bir arama yapıldı. PubMed, Web of Science, Cochrane, Science Direct, Ovid, EBSCO, Wiley ve Google Scholar'da rastgele kontrollü denemeler aradık. Sonuçlar Toplam yedi çalışmada 1233 hasta bulundu. PDT ve kriyoterapi, lezyonları temizlemede benzer başarı gösterdi (RR, 1.02; %95 GA, 0.92–1.13; p = 0.74). Her iki tedavi de baş ve yüz üzerinde benzer şekilde sonuç vermiş olsa da (RR, 1,10; %95 GA, 0,94–1,28; p = 0,24), bir çalışmadan elde edilen veriler kriyoterapinin kol ve bacaklardaki lezyonlar için daha etkili olabileceğini öne sürmüştür (RR, 0,88; %95 GA, 0,82–0,94; p < 0,05). Ancak, bu bulguyu doğrulamak için daha fazla araştırmaya ihtiyaç vardır. Kozmetik sonuçlar PDT için (%74,62 vs. %49,11: RR, 1,52; %95 GA, 1,4–1,65; p < 0,00001) kriyoterapiye göre anlamlı derecede daha iyiydi. Benzer şekilde, PDT hasta memnuniyetinde kriyoterapiye göre üstündü, ancak genel fark istatistiksel olarak anlamlı değildi (RR, 1,43; %95 GA, 0,91–2,25; p = 0,12). PDT, yanma hissi ve ağrı riski açısından anlamlı daha yüksek bir durumla ilişkilendirildi (RR, 1,95; %95 GA, 1,27–3,02; p = 0,002), oysa kriyoterapi daha sık veziküller ve kabarcıklara yol açtı. Sonuç Lezyon temizliği konuma bağlı olabilir. Baş ve yüz lezyonları için karşılaştırılabilirken, bir çalışmadan elde edilen veriler ekstremite lezyonları için kriyoterapinin daha iyi olabileceğini gösteriyor. PDT daha fazla ağrı/yanma ile ilişkilidirken, kriyoterapi daha fazla vezikül/su kabarmasına yol açar. Gelecekteki araştırmalar, güvenilirliği artırmak ve önyargıyı en aza indirmek için kör tedavi sonrası değerlendirmeler dahil olmak üzere standart protokollere odaklanmalıdır.","title_en":"Comparative Efficacy of Photodynamic Therapy Versus Cryotherapy for Actinic Keratosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","abstract_source":"crossref"},"openalex_id":"pmc:13069436","doi":"10.1111/jocd.70749","title":"Comparative Efficacy of Photodynamic Therapy Versus Cryotherapy for Actinic Keratosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","publication_year":2026,"type":"article","cited_by_count":0,"is_open_access":true,"pdf_url":null,"abstract":"ABSTRACT Background Photodynamic therapy and cryotherapy are treatment options for actinic keratosis; however, their efficacy and safety remain debated. Aims To perform a high‐quality systematic review and meta‐analysis exploring the efficacy and safety of photodynamic therapy and cryotherapy in actinic keratosis. Methods A systematic search was performed applying the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. We searched PubMed, Web of Science, Cochrane, Science Direct, Ovid, EBSCO, Wiley, and Google Scholar for randomized controlled trials. Results A total of seven studies with 1233 patients were identified. PDT and cryotherapy showed similar success in clearing lesions (RR, 1.02; 95% CI, 0.92–1.13; p = 0.74). While both treatments performed comparably on the head and face (RR, 1.10; 95% CI, 0.94–1.28; p = 0.24), data from one trial suggested cryotherapy might be more effective for lesions on the arms and legs (RR, 0.88; 95% CI, 0.82–0.94; p < 0.05). However, more research is needed to confirm this finding. Cosmetic outcomes were significantly better for PDT (74.62% vs. 49.11%: RR, 1.52; 95% CI, 1.4–1.65; p < 0.00001) than cryotherapy. Similarly, PDT was superior to cryotherapy in patient satisfaction though the overall difference was not statistically significant (RR, 1.43; 95% CI, 0.91–2.25; p = 0.12). PDT was associated with a significantly higher risk of burning sensations and pain (RR, 1.95; 95% CI, 1.27–3.02; p = 0.002), whereas cryotherapy more frequently led to vesicles and blisters. Conclusion Lesion clearance may depend on location. It is comparable for head and face lesions, while data from one trial suggests cryotherapy may be better for extremity lesions. PDT is associated with a higher occurrence of pain/burning, while cryotherapy leads to more vesicles/blisters. Future research should focus on standardized protocols, including blinded post‐treatment assessments to improve reliability and minimize bias.","source_name":"J Cosmet Dermatol","source_issn":null,"volume":null,"issue":null,"first_page":null,"last_page":null,"language":"en","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069436/","is_relevant":true,"thesis_level":null,"title_tr":"Aktinik Keratoz için Fotodinamik Terapi ile Kriyoterapinin Karşılaştırmalı Etkinliği: Randomize Kontrollü Çalışmaların Sistematik Gözden Geçirmesi ve Meta-Analizi.","license_code":null,"license_url":null,"doi_status":"unknown","doi_last_checked":null,"merged_at":null,"lens_id":"178-378-339-517-712","patent_cited_by_count":null,"oa_colour":"Green","created_at":"2026-04-28T04:31:16.983740+03:00","updated_at":"2026-06-03T13:12:46.109472+03:00","publisher":null,"merged_into":null}