{"id":"a497aaef-876c-406f-b1d1-4a3e84e8bd45","authors":[{"author":{"id":"0ce8d706-3557-48f7-9175-5acef2751130","openalex_id":"pmc:author:egger_m","orcid":null,"display_name":"Egger M","works_count":4,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"3177a742-796c-4acb-a0f0-956d8a735b79","openalex_id":"pmc:author:williams_sa","orcid":null,"display_name":"Williams SA","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"4c347d9d-7759-471d-99ab-e478b4c77f69","openalex_id":"pmc:author:golub_rm","orcid":null,"display_name":"Golub RM","works_count":4,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"63d004e2-650e-4e36-8a2b-d891f6f037ec","openalex_id":"pmc:author:rizzo_rrn","orcid":null,"display_name":"Rizzo RRN","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"66c9feca-cd41-4926-b5b5-085a6b112670","openalex_id":"pmc:author:swanson_sa","orcid":null,"display_name":"Swanson SA","works_count":3,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"7f159059-fd58-443c-aa4c-1abfccbf05b4","openalex_id":"pmc:author:cashin_ag","orcid":null,"display_name":"Cashin AG","works_count":4,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"87be9cfd-8bde-4fc8-8129-7613911bd17c","openalex_id":"pmc:author:jones_md","orcid":null,"display_name":"Jones MD","works_count":3,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"9f7f6de2-445f-4db8-80d4-be70ad8fc436","openalex_id":"pmc:author:dahabreh_ij","orcid":null,"display_name":"Dahabreh IJ","works_count":3,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"a45797fd-b598-4fbb-9d9e-d9a21cd564fe","openalex_id":"pmc:author:devonshire_jj","orcid":null,"display_name":"Devonshire JJ","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"bc5eea33-c17b-495a-bce1-e2cd55cb6fb3","openalex_id":"pmc:author:lodi_s","orcid":null,"display_name":"Lodi S","works_count":4,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"last"},{"author":{"id":"c31c0385-1d46-44b2-9192-421c7fb53833","openalex_id":"pmc:author:douglas_srg","orcid":null,"display_name":"Douglas SRG","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"cc855063-c434-45cd-9b00-c8982a086d50","openalex_id":"pmc:author:garcia_albeniz_x","orcid":null,"display_name":"Garcia-Albeniz X","works_count":3,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"de0dad4d-cae9-4dde-82c9-b0b14a48af3c","openalex_id":"pmc:author:dickerman_ba","orcid":null,"display_name":"Dickerman BA","works_count":4,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"e2029136-7518-4430-988a-d6133cc93ae0","openalex_id":"pmc:author:islam_n","orcid":null,"display_name":"Islam N","works_count":113,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"ef61b170-db01-4ac6-b44c-a6d475da715f","openalex_id":"pmc:author:hansford_hj","orcid":null,"display_name":"Hansford HJ","works_count":4,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"first"}],"concepts":[],"publisher_name":null,"publisher_website_url":null,"publisher_info":null,"bib_extra":[],"journal_info":null,"raw_data":{"abstract_tr":"Önem Randomize bir denemeyi (yani hedef denemeyi) taklit etmeyi amaçlayan gözlemsel (deneysel olmayan) çalışmalar, tıbbi ve politika kararlarını giderek daha fazla bilgilendirmektedir, ancak bu çalışmaların literatürde nasıl bildirildiği belirsizdir. Tutarlı raporlama, kaliteli değerlendirme, kanıt sentezi ve kanıtların politika ile uygulamaya aktarılması için gereklidir. Amaç: Hedef denemeyi taklit etmeyi amaçlayan gözlemsel çalışmaların raporlanmasını değerlendirmek. Delil İnceleme Medline, Embase, PsycINFO ve Web of Science'da Mart 2012 ile Ekim 2022 arasında yayımlanan ve açıkça bir sağlık veya tıbbi müdahalenin hedef denemesini taklit etmeyi amaçlayan gözlemsel çalışmaları aradık. İki incelemeci, çalışma özellikleri, hedef deneme protokolünün ve emülasyonunun önceden tanımlanmış temel bileşenleri (uygunluk kriterleri, tedavi stratejileri, tedavi ataması, sonuçlar, takip, nedensel kontrastlar ve analiz planı) ve hedef deneme emülasyonuyla ilgili diğer maddeler hakkında çift tarama ve veri çıkardı. Bulgular Hedef denemeyi açıkça taklit etmeyi amaçlayan toplam 200 çalışma dahil edildi. Bu çalışmalar 26 tıp alt dalını kapsıyordu ve Ocak 2020'den Ekim 2022'ye kadar 168 alt dalı (%84) yayımlandı. Hedef denemeyi taklit etme amacı, 70 çalışma başlığında (%35) açıkça belirtilmişti. Kırk üç çalışma (%22), yayımlanmış bir raporlama rehberinin kullanıldığını bildirdi (örneğin, Epidemiyolojide Gözlemsel Çalışmaların Raporlamasını Güçlendirmek). Seksen beş çalışma (%43) hedef denemenin nasıl taklit edildiğine dair tüm temel unsurları tanımlamadı ve 113'ü (%57) hedef denemenin protokolünü ve emülasyonunu tanımlamadı. Sonuçlar ve İlgililik Hedef denemeyi taklit etmeyi amaçlayan bu sistematik incelemede, hedef denemenin nasıl taklit edildiğine dair raporlama tutarsızdı. Hedef denemeyi açıkça taklit etmeyi amaçlayan çalışmalar için bir raporlama rehberi, hedef deneme protokollerinin raporlanmasını ve bu emülasyonların diğer yönlerini iyileştirebilir","title_en":"Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.","abstract_source":"crossref"},"openalex_id":"pmc:10534275","doi":"10.1001/jamanetworkopen.2023.36023","title":"Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.","publication_year":2023,"type":"article","cited_by_count":89,"is_open_access":true,"pdf_url":null,"abstract":"Importance Observational (nonexperimental) studies that aim to emulate a randomized trial (ie, the target trial) are increasingly informing medical and policy decision-making, but it is unclear how these studies are reported in the literature. Consistent reporting is essential for quality appraisal, evidence synthesis, and translation of evidence to policy and practice. Objective To assess the reporting of observational studies that explicitly aimed to emulate a target trial. Evidence Review We searched Medline, Embase, PsycINFO, and Web of Science for observational studies published between March 2012 and October 2022 that explicitly aimed to emulate a target trial of a health or medical intervention. Two reviewers double-screened and -extracted data on study characteristics, key predefined components of the target trial protocol and its emulation (eligibility criteria, treatment strategies, treatment assignment, outcome[s], follow-up, causal contrast[s], and analysis plan), and other items related to the target trial emulation. Findings A total of 200 studies that explicitly aimed to emulate a target trial were included. These studies included 26 subfields of medicine, and 168 (84%) were published from January 2020 to October 2022. The aim to emulate a target trial was explicit in 70 study titles (35%). Forty-three studies (22%) reported use of a published reporting guideline (eg, Strengthening the Reporting of Observational Studies in Epidemiology). Eighty-five studies (43%) did not describe all key items of how the target trial was emulated and 113 (57%) did not describe the protocol of the target trial and its emulation. Conclusions and Relevance In this systematic review of 200 studies that explicitly aimed to emulate a target trial, reporting of how the target trial was emulated was inconsistent. A reporting guideline for studies explicitly aiming to emulate a target trial may improve the reporting of the target trial protocols and other aspects of these emulation attempts.","source_name":"JAMA Netw Open","source_issn":null,"volume":null,"issue":null,"first_page":null,"last_page":null,"language":"en","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534275/","is_relevant":true,"thesis_level":null,"title_tr":"Rastgele Denemeleri Taklit Etmeyi Amaçlayan Gözlemsel Çalışmaların Raporlanması: Sistematik Bir İnceleme.","license_code":"CC BY, CC BY-NC-ND","license_url":null,"doi_status":"unknown","doi_last_checked":null,"merged_at":null,"lens_id":"088-828-931-356-607","patent_cited_by_count":null,"oa_colour":"Gold","created_at":"2026-05-14T10:29:42.922534+03:00","updated_at":"2026-05-15T13:19:20.995924+03:00","publisher":null,"merged_into":null}