{"id":"ecac854b-24df-45d6-9b06-c7c064d72d88","authors":[{"author":{"id":"2b746f8f-7807-4558-94b6-46ae2bd32fad","openalex_id":"pmc:author:vakili_f","orcid":null,"display_name":"Vakili F","works_count":5,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"4f934546-27f2-47c3-bf20-14e3bf4a82ac","openalex_id":"pmc:author:baratinamin_m","orcid":null,"display_name":"Baratinamin M","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"58f3660d-dea7-4471-b3c6-5d11434e2ce5","openalex_id":"pmc:author:zafarjafarzadeh_n","orcid":null,"display_name":"Zafarjafarzadeh N","works_count":2,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"64c66cc5-cf6f-4ed1-bd2b-5b3784b7cc8c","openalex_id":"pmc:author:karimi_kordestani_b","orcid":null,"display_name":"Karimi Kordestani B","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"6cfcd443-882c-443b-a371-715d8c7224a1","openalex_id":"pmc:author:mashaollahi_a","orcid":null,"display_name":"Mashaollahi A","works_count":2,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"9333299e-ad36-4702-a27a-a9bf6d4bd0b5","openalex_id":"pmc:author:mohammadpour_s","orcid":null,"display_name":"Mohammadpour S","works_count":2,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"last"},{"author":{"id":"9cd312c4-182b-4e5c-b139-86a6ef02fd9e","openalex_id":"pmc:author:bizhanpour_a","orcid":null,"display_name":"Bizhanpour A","works_count":2,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"middle"},{"author":{"id":"a6ad534f-0b12-44fe-aafe-f4e38bf02f14","openalex_id":"pmc:author:torshizi_esfahani_a","orcid":null,"display_name":"Torshizi Esfahani A","works_count":1,"cited_by_count":0,"h_index":0,"last_institution":null,"country_code":null},"position":"first"}],"concepts":[],"publisher_name":null,"publisher_website_url":null,"publisher_info":null,"bib_extra":[],"journal_info":null,"raw_data":{"abstract_tr":"Özet: Kolorektal kanser (KK) küresel sağlık açısından büyük bir zorluktur. Yeni araştırmalar, bağırsak mikrobiyotasının KK riski, ilerlemesi ve tedavi yanıtını etkilemedeki merkezi rolünü vurgulamaktadır. Metagenomik yaklaşımlar, özellikle yüksek verimli kesme dizileme, bağırsak mikrobiyomu ile KK arasındaki karmaşık bağlantılara dair eşi benzeri görülmemiş içgörüler sağlamıştır. Kapsamlı bir şekilde sağlamak için","title_en":"Gut microbiome in colorectal cancer: metagenomics from bench to bedside.","abstract_source":"crossref"},"openalex_id":"pmc:12105612","doi":"10.1093/jncics/pkaf026","title":"Gut microbiome in colorectal cancer: metagenomics from bench to bedside.","publication_year":2025,"type":"article","cited_by_count":9,"is_open_access":true,"pdf_url":null,"abstract":"Abstract Colorectal cancer (CRC) is a major global health challenge. Emerging research highlights the pivotal role of the gut microbiota in influencing CRC risk, progression, and treatment response. Metagenomic approaches, especially high-throughput shotgun sequencing, have provided unprecedented insights into the intricate connections between the gut microbiome and CRC. By enabling comprehensive taxonomic and functional profiling, metagenomics has revealed microbial signatures, activities, and biomarkers associated with colorectal tumorigenesis. Furthermore, metagenomics has shown a potential to guide patient stratification, predict treatment outcomes, and inform microbiome-targeted interventions. Despite remaining challenges in multi-omics data integration, taxonomic gaps, and validation across diverse cohorts, metagenomics has propelled our comprehension of the intricate gut microbiome-CRC interplay. This review underscores the clinical relevance of microbial signatures as potential diagnostic and prognostic tools in CRC. Furthermore, it discusses personalized treatment strategies guided by this omics’ approach.","source_name":"JNCI Cancer Spectr","source_issn":null,"volume":null,"issue":null,"first_page":null,"last_page":null,"language":"en","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105612/","is_relevant":true,"thesis_level":null,"title_tr":"Kolorektal kanserde bağırsak mikrobiyomu: bench'ten yatak başına metagenomik.","license_code":"CC BY, CC BY-NC, CC BY-NC-ND","license_url":null,"doi_status":"unknown","doi_last_checked":null,"merged_at":null,"lens_id":"182-606-421-520-036","patent_cited_by_count":null,"oa_colour":"Gold","created_at":"2026-05-05T04:59:17.689050+03:00","updated_at":"2026-05-05T04:59:17.689295+03:00","publisher":null,"merged_into":null}